By Professor Dr. Frank G. Holz, Professor Dr. Daniel Pauleikhoff, MD Richard F. Spaide, Professor Alan C. Bird (auth.)
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Extra resources for Age-related macular degeneration
Mol Vis 6:287-293 Seddon JM, Ajani UA, Mitchell BD (1997) Familial aggregation of age-related maculopathy. Am J Ophthalmol 123:199- Dailey JP, Ferrell RE, Gorin MB (2000) A full genome scan for age-related maculopathy. Genetics of AMD Weng J. Mata NL. Azarian SM. Tzekov RT. Birch DG. Travis GH (1999) Insights into the function of Rim protein in photo receptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell 98:13-23 Yoshida A. Yoshida M. Yoshida S. Shiose S. Jpn J OphthalmoI44:290-295 3 Frank G.
Ophthalmologica 213:165-170 Silvestri G,Johnston PB, Hughes AE (1994) Is genetic predisposition an important risk factor in age-related macular degeneration? Eye 8:564-568 Smith W, Mitchell P (1998) Family history and age-related maculopathy: the Blue Mountains Eye Study. Aust N Z J OphthalmoI26:203-206 Souied EH, Benlian P, Amouyel P, Feingold J, Lagarde JP, Munnich A, Kaplan J, Coscas G, Soubrane G (1998)The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration.
Intercellular junctional complexes (J) are present between neighboring cells. The apical membrane has numerous microvilli that are subdivided into two types: long, small microvilli (MI) that are not in contact with the outer segments of the photoreceptors and shorter microvilli that form a sheath for the outer segments (PS). At the basal RPE cell site there are multiple invaginations (I); underneath is Bruch's membrane. The cytoplasm of the RPE cell contains various organelles, including the nucleus (N), melanin (M) and lipofuscin granula (L ) processes may result in incomplete catabolism of phagocytosed material and subsequent accumulation of biomolecules, both within the RPE cell as lipofuscin and/or in the extracellular matrix of Bruch's membrane as drusen.
Age-related macular degeneration by Professor Dr. Frank G. Holz, Professor Dr. Daniel Pauleikhoff, MD Richard F. Spaide, Professor Alan C. Bird (auth.)