By Adekunle M. Adesina, Tarik Tihan, Christine E. Fuller, Tina Young Poussaint
This textual content was once created to fill a void within the perform of pediatric neuropathology. it's a sensible and well-illustrated bookrepresenting a suite of attention-grabbing, universal and strange tumors for a diagnostic workout through the reader. The vast reception of the 1st version via the pathology group is testomony to its relevance and application within the pathologic prognosis of pediatric mind tumors. This version covers themes starting from neuroimaging, using weigh down and contact preps in the course of intraoperative session, vintage histological positive aspects of pediatric mind tumors, tumor versions, and a miscellaneous workforce of hard tumors. Chapters include crucial diagnostic details and lines highlighting famous editions and their differential diagnoses. a bit on molecular pathology and electron microscopy is usually integrated for every tumor type, in addition to a listing of vintage stories and cutting edge articles on all the tumor entities as instructed studying on the finish of every bankruptcy. Atlas of Pediatric mind Tumors, moment Edition represents the state-of-the-art in pediatric neuropathology with effortless software beside the microscope.
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Extra info for Atlas of Pediatric Brain Tumors
Cancer Cell. 2012;22:425–37. Thorarinsdottir HR, Santi M, McCarter R, Rushing EJ, Cornelison R, Jales A, et al. Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas. Clin Cancer Res. 2008;14: 3386–94. Wu G, Broniscer A, McEachron T, Lu C, Paugh BS, Becksfort J, et al. Somatic histone H3 alterations in paediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012;44: 251–3. Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, et al.
Brain Pathol. 2014;24:221–9. Lacoste-Collin L, d'Aure D, Aziza J, Quintyn ML, Uro-Coste E, CourtadeSaidi M. Cerebrospinal ﬂuid cytologic ﬁndings of a pleomorphic xanthoastrocytoma: a case report. Acta Cytol. 2010;54:871–4. Perkins SM, Mitra N, Fei W, Shinohara ET. Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis. J Neurooncol. 2012;110:99–104. Rao AA, Laack NN, Giannini C, Wetmore C. Pleomorphic xanthoastrocytoma in children and adolescents. Pediatr Blood Cancer.
5B). ° High-grade lesions, not surprisingly, are obviously hypercellular, often with mitotic ﬁgures identiﬁable on cytology preparations. ° Vascular proliferation and a “dirty” necrotic background are features supportive of glioblastoma (Fig. 5C and D). • Histology: Four histologic criteria are utilized in the grading of inﬁltrative astrocytomas: nuclear atypia, mitosis, necrosis, and/or microvascular proliferation. Tumor grade is established based on the area of greatest anaplasia. ° A note of caution in grading: Occasional mitoses are acceptable in a large sample, but detection of any mitotic ﬁgure within a tiny sample warrants upgrading to high-grade astrocytoma (at least anaplastic astrocytoma).
Atlas of Pediatric Brain Tumors by Adekunle M. Adesina, Tarik Tihan, Christine E. Fuller, Tina Young Poussaint