Download e-book for kindle: Biochemical Actions of Hormones. Volume 13 by Gerald, Editor; Litwack

By Gerald, Editor; Litwack

ISBN-10: 0124528139

ISBN-13: 9780124528130

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Extra info for Biochemical Actions of Hormones. Volume 13

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The effects of these agents appear to be imposed on both the sensitivity of the cells to insulin and the intrinsic activity of those glucose transporters present in the plasma membrane; the combination of these actions of the lipolytic hormones is a marked reduction in glucose transport activity in the presence of insulin while the antilipolytic hormones reverse these effects. The ability of these agents to modulate glucose transport thus completes the interrelationship between lipolysis and lipogenesis.

In the presence of 10~8 M Dex alone (Experiment 3) cell transformation takes place in 7 to 10 days as evident from the formation of numerous foci exhibiting irregular overgrowth. Upon transfer of 500 cells into 60-mm plates containing soft agar large numbers of anchorage independently growing colonies of greatly variable size develop during the subsequent 2 weeks of culture (Experiment 3). For each experiment four parallel plates were counted. 2 mm in diameter (Experiment 3), therefore, the n u m b e r of colonies alone (as given in the table) does not portray realistically the large degree of transformation by dexamethasone (Experiment 3).

Simpson, I. , Hissin, P. , and Cushman, S. W. (1984). Proc. Gen. Physiol. Soc. A. 39, 43-55. Smith, M. , Robinson, F. , and Kono, T. (1984). Biochim. Biophys. Acta 775, 121-128. , and Simpson, I. A. /. Biol. Chem. 259, 8758-8763. Sogin, D. C , and Hinkle, P. C. (1980). Proc. Natl. Acad. Sei. A. 77, 5725-5729. , and Simpson, I. A. (1984). Biochim. Biophys. Acta 804, 404-413. Strader, C. , Sibler, D. , and Lefkowitz, R. J. (1984). Life Set. 35, 1601-1610. , and Kono, T. (1980). Proc. Natl. Acad. Sei.

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Biochemical Actions of Hormones. Volume 13 by Gerald, Editor; Litwack


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