By Gerald Litwack
ISBN-10: 0124528031
ISBN-13: 9780124528031
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68, 2799. , and Sherman, F. G. (1959). Exp. Cell Res. 17, 420. Salmon, W. , and Daughaday, W. D. /. Lab. Clin. Med. 49, 825. , and Cintron, R. (1973). Science 181, 1253. , and Casanova, J. (1974). Science 184, 1188. , and Mills, S. E. (1960). Proc. Nat. Acad. Set. S. 46, 963. , and Sato, G. (1968). Endocrinology 82, 614. Smith, J. , and Martin, L. (1973). Proc. Nat. Acad. Sei. S. 70, 1263. Steel, G. G. (1972). Cell Tissue Kinet. 5, 87. , and Parker, M. (1968). Endocrinology 82, 342. Temin, H. M.
1969). Science 166, 1474. Weiss, M. , and Green, H. (1967). Proc. Nat. Acad. Sei. U. S. 58, 1104. , Visser, R. P. L. , Khan, P. , and Bootsma, D. (1971). Nature (London) New Biol. 234, 20. CHAPTER 3 Studies on the Interaction of Hormones with Plasma Membrane Receptors M. D. Hollenberg and P. Cuatrecasas I. Introduction II. General Properties of Ligand-Receptor Interactions and Tech nical Considerations A. Number and Affinity of Membrane Receptors B. Rate of Association and Dissociation C. The Problem of Specific Versus Nonspecific Binding III.
5 ML F I G . 2. Displacement by native insulin of 125 I-insulin bound to isolated fat cells. 9 x 10~ n M 125 I-insulin and increas ing amounts of native insulin. ) physiological range of hormone concentration (Fig. 1, upper), and there is an excellent correlation between the binding curve and the dose-response curve for glucose oxidation (Fig. 1, lower). 125 I-insulin bound in small amounts to fat cells is displaced by increasing amounts of native insulin in a manner predicted by the near identity of these two molecules (Fig.
Biochemical Actions of Hormones. Volume 3 by Gerald Litwack
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