Biopsy Pathology of Muscle - download pdf or read online

By Michael Swash M.D. (London), F.R.C.P. (London), M.R.C. Path., Martin S. Schwartz M.D. (Maryland) (auth.)

ISBN-10: 0412348802

ISBN-13: 9780412348808

ISBN-10: 1489934006

ISBN-13: 9781489934000

Museie biopsy is a original procedure in medical perform having been brought through Duchenne in 1868 (Arch. Gen. Med. , eleven, 5-179). in spite of the fact that, the needle approach utilized by Duchenne used to be now not in general followed, even if Shank and Hoagland defined the same approach in 1943 (Science, ninety eight, 592), and open muscle biopsy has for lengthy been most popular in scientific perform, despite the appearance of more moderen needle biopsy equipment (Bergstrom, 1962, Scand. J. Clin. Lab. make investments. , 14, Suppl. sixty eight, 1-110). the improvement of enzyme histochemical recommendations has contributed drastically to wisdom of muscle pathology. extra lately electron microscopy and immunocytochemistry have additionally been utilized to medical analysis of neuromuscular ailment. This ebook is meant to function a realistic advisor in muscle pathology, really for histopathologists, and for these in education. As enzyme histochemistry has turn into extra generally to be had, formalin-fixed tools became much less usually utilized in muscle biopsy paintings. during this re-creation of Muscle Biopsy Pathology we now have taken account of the advances in type and histological approach, and in wisdom of neuromuscular ailments, that experience emerged because the first editionwas released in 1984. we are hoping that this ebook will remain used as a pragmatic consultant within the prognosis and knowing of those issues. 1. creation 1. 1 Generalfeatures of muscle The differentiation of musde into pink and white kinds is a function of all vertebrates and, certainly, of chordates.

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Extra resources for Biopsy Pathology of Muscle

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These connective tissue septa contain elastic tissue. (a) (b) Fig. 4 Museie spindie in transverse section. x 560. (a) Gomori trichrome. The spindie capsule, periaxial space and intrafusal muscle fibres can be seen. These fibres are much smaller than the extrafusal skeletal muscle fibres themselves. 6. There are three histochemical types of intrafusal muscle fibre in this reaction; darkly reactive, small nuclear chain fibres; and intermediate, and lightly reactive nuclear bag fibres. The capsule is virtually non-reactive.

Fig. 2 (a) Infant muscle (aged 2 years). 6. The three fibre types are weil developed, but the muscle fibres are very much smaller than in the adult. The fascicular pattern can be clearly seen. 6. There is a mosaic distribution ofType 1 (dark), Type 2A (pale) and Type 2B (intermediate) fibres, with approximately equal numbers of fibres of each type. This muscle is normal, apart from the presence of a few, isolated, small Type 1 fibres. The interfascicular planes can be clearly recognized. 2 Fibre-type distribution Museie fibres are distributed in a mosaic pattern of the different fibre types, the mosaic approximately conforming to a random distribution.

2 (a) Infant muscle (aged 2 years). 6. The three fibre types are weil developed, but the muscle fibres are very much smaller than in the adult. The fascicular pattern can be clearly seen. 6. There is a mosaic distribution ofType 1 (dark), Type 2A (pale) and Type 2B (intermediate) fibres, with approximately equal numbers of fibres of each type. This muscle is normal, apart from the presence of a few, isolated, small Type 1 fibres. The interfascicular planes can be clearly recognized. 2 Fibre-type distribution Museie fibres are distributed in a mosaic pattern of the different fibre types, the mosaic approximately conforming to a random distribution.

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Biopsy Pathology of Muscle by Michael Swash M.D. (London), F.R.C.P. (London), M.R.C. Path., Martin S. Schwartz M.D. (Maryland) (auth.)


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