By Carlos A. Zarate Jr., Husseini K. Manji
Even supposing our wisdom of temper issues generally is increasing progressively, relatively little is understood approximately bipolar melancholy particularly. This ebook brings jointly top clinicians and preclinical and medical researchers to supply the main up to date information regarding the analysis, remedy, and examine surrounding bipolar melancholy. Early chapters supply worthwhile diagnostic info, and evaluation the direction, final result, and genetics of this hugely heritable , permitting clinicians to differentiate among a number of the temper problems. The e-book deals a radical and exact evaluate of the neurobiology of the illness, together with what's recognized from fresh neuroimaging paintings. a number of chapters delineate the therapy of bipolar melancholy in specified populations resembling childrens and pregnant ladies, and one other bankruptcy addresses the actual problems with suicide, targeting the necessity for evaluation in the course of either acute and upkeep therapy with interventions acceptable to a patient's indicators and historical past. ultimately, the booklet covers acute and long term therapy suggestions for bipolar melancholy, together with either conventional and novel therapeutics for the disease, in addition to non-pharmacological remedies. This booklet has assembled a generally revered team of preclinical and medical researchers who convey their services to undergo upon this ailment. It bargains researchers, clinicians, and postgraduate scholars key insights into this devastating disease.
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Extra info for Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy)
Chronicity, seasonal pattern, or rapid cycling). As major depression is not a specific diagnosis  and more an operational strategy to differentiate ‘clinical depression’ from less substantive depressive disorders, such specifiers are likely to be more salient in determining and quantifying whether ‘bipolar depression’ is more, or less, likely to be distinctive. The ICD-10 system  adopts a dimensional model for the depressive disorders, operating across severity, persistence, and recurrence parameters.
First, it could be defined, as indicated in the ‘top down’ section, by studying those with BPD during the depressed phase. However, this descriptive approach is only of modest value as it lacks specificity. The more substantive second problem is whether bipolar depression is ‘different’ or ‘distinctive’ from unipolar depression, and the issue here is in considering and studying the appropriate reference group. Let us consider the limitations to any comparison with ‘major depression’ or ‘clinical depression’.
Treuer and M. Tohen While identifying and treating the illness early in its time course may be associated with a better prognosis, there are several barriers to early identification; the delay from the first episode of illness to a diagnosis of bipolar disorder is approximately 10 years . This delay poses a threat for the effectiveness of early treatment intervention, especially because data suggest that beginning lithium therapy within the first 10 years of illness may provide better outcomes than beginning prophylaxis later in life for patients with bipolar disorder .
Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy) by Carlos A. Zarate Jr., Husseini K. Manji