By Barbara J. Bain, David M. Clark, Bridget S. Wilkins
Bone Marrow Pathology has been greatly revised to mirror the numerous advances that have happened within the software of cytogenetics and particularly, molecular genetics within the analysis, category and realizing of haematological issues. This accomplished e-book not just presents info on all universal disorder entities, but in addition covers infrequent issues during which bone marrow exam turns out to be useful. it's designed as useful source with ‘Problems and Pitfalls’ sections all through to assist laboratory diagnosis.This fourth edition:Incorporates the strategies of the 2008 WHO class of Tumours of Haematopoietic and Lymphoid TissuesCovers key diagnostic ideas resembling circulation cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysisIncludes new diagnostic algorithms and precis boxesContains 550 color illustrations together with high quality electronic photomicrographs Haematologists and histopathologists will locate this e-book a useful computing device reference while appearing day-by-day blood and bone marrow investigations.
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Additional info for Bone Marrow Pathology, Fourth edition
28) are identified as irregularly scattered, relatively large cells with a small nucleus and abundant cytoplasm. In thin sections, only the cytoplasm may be visible, the nucleus being out of the plane of the section. Phagocytosed debris may be prominent in the cytoplasm. Some are associated with erythroblasts (forming erythroblastic islands), plasma cells or lymphoid nodules. Immunohistochemistry of trephine biopsy sections highlights a prominent network of dendritic macrophages dispersed through the stroma (Fig.
Typical mature plasma cells in histological sections are readily identified by their eccentric nuclei and prominent Golgi zones. The chromatin is coarsely clumped and often distributed at the periphery of the nucleus with clear spaces between the chromatin clumps, giving the appearance of a cartwheel or clock-face. In Giemsa-stained sections the cytoplasm, with the exception of the Golgi zone, is deeply basophilic. TH E N OR M A L B ON E M A R R OW 33 Fig. 50 Aspirate of BM from a patient with an inflammatory condition: three plasma cells; note the basophilic cytoplasm, eccentric nucleus and Golgi zone adjacent to the nucleus.
Cytology Bone marrow lymphocytes are small cells with a high nucleocytoplasmic ratio and scanty, weakly basophilic cytoplasm. The nuclei show some chromatin condensation but the chromatin often appears more diffuse than that of peripheral blood lymphocytes. Lymphocytes are not very numerous in the marrow in the first few days of life but otherwise during infancy they constitute a third to a half of bone marrow nucleated cells . Numbers decline during childhood and in adults they do not generally comprise more than 15–25% of nucleated cells, unless the marrow aspirate has been considerably diluted with peripheral blood.
Bone Marrow Pathology, Fourth edition by Barbara J. Bain, David M. Clark, Bridget S. Wilkins