By Davide Schiffer
The aim and aim of this paintings it to provide the pathology of mind tumors interpreted by means of its organic correlates. additionally, greater realizing of the various oncological and neuropathological difficulties of mind tumors in addition to larger figuring out of neuro-imaging prognostic difficulties.
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Extra info for Brain Tumors: Pathology and its Biological Correlates
The gene most frequently amplified in malignant gliomas is erbBl, coding the epidermal growth factor receptor (EGFR) [1644, 3071]. The EGFR belongs to a group of products of oncogenes having phosphotyrosine kinase activity. There is evidence that this activity is crucial in the mechanisms of neoplastic transformation involving numerous oncogenes [1226, 1227,216]. In response to the binding with EGF, the receptor is capable of autophosphorylation on tyrosine residues and of analogous phosphorylation of numerous other proteins, activating a cascade of biochemical events which transmit a mitogenic signal and induce cell proliferation [1226, 524, 374].
1b). u. U11, with higher cell density, frequent mitoses, and proliferation centers of densely packed cells, develop from these lesions . 2b). Isomorphous tumors develop from microtumors and become polymorphous. 3) develop from oligodendroglial foci and may become polymorphous. Malignant growth is reached at the stage of microtumors . 4. , " to ... , , ,", " ~ I " . 2a,b. Rat transplacentally treated with ENU. a Microtumor, H&E, x200. b Oligodendroglia! 5). Neurinomas represent 41 % of all experimental tumors and occur more frequently (53%) in postnatal induction experiments .
2a,b. Rat transplacentally treated with ENU. a Microtumor, H&E, x200. b Oligodendroglia! 5). Neurinomas represent 41 % of all experimental tumors and occur more frequently (53%) in postnatal induction experiments . 3. 4. 7). In culture, they grow rapidly, and their cells are similarto Schwann cells [513, 801, 1870]. If transplanted into subcutaneous tissue or the brain, they do not differ from those of the original tumor . 1 Chemical Carcinogenesis 33 . ,;: .. 5. 6. Rat transplacentally treated with ENU; neurinoma of the Gasser ganglion neurofibromas, appear.
Brain Tumors: Pathology and its Biological Correlates by Davide Schiffer