By Baldev K. Vig (auth.), Baldev K. Vig (eds.)
Aneuploidy - the best genetic ailment of guy - has its starting place in manycellular strategies. Its forerunner, chromosome non-disjunction, may result from malfunction of 1 of many techniques inquisitive about devoted segregation of chromosomes in the course of mitosis or meiosis. specialists on chromosome biology,centromere, kinetochore, microtubules, spindle equipment, biochemistry of mitosis and meiosis, developmental biology, and environmental mutagenesis speak about easy and utilized points of ways chromosomes malsegregate and the way aneuplody originates. the newest recommendations hired to check chromosome segregation and in addition how to be certain aneugenic chemical compounds are defined.
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Although we have yet to conclusively identify the cis-acting DNA sequences required for centromere formation, several approaches to this problem have uncovered some interesting potential candidates, and these will be discussed as well. Lastly, we will summarize the recent evidence which suggests that the centromere may participate in cell cycle regulation. Before describing the centromere components, it will be useful to begin with a brief review of centromere morphology. Morphology of the mammalian centromere By the early 1930's, cytologists including Schrader(Schrader, 1936), Lorbeer(Lorbeer, 1934) and Sharp (Sharp, 1929) had reported on a structure which formed on the surface of the chromosome at the major constriction.
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Chromosome Segregation and Aneuploidy by Baldev K. Vig (auth.), Baldev K. Vig (eds.)