Download e-book for kindle: Chromosome Segregation and Aneuploidy by Baldev K. Vig (auth.), Baldev K. Vig (eds.)

By Baldev K. Vig (auth.), Baldev K. Vig (eds.)

ISBN-10: 3642849385

ISBN-13: 9783642849381

ISBN-10: 3642849407

ISBN-13: 9783642849404

Aneuploidy - the best genetic ailment of guy - has its starting place in manycellular strategies. Its forerunner, chromosome non-disjunction, may result from malfunction of 1 of many techniques inquisitive about devoted segregation of chromosomes in the course of mitosis or meiosis. specialists on chromosome biology,centromere, kinetochore, microtubules, spindle equipment, biochemistry of mitosis and meiosis, developmental biology, and environmental mutagenesis speak about easy and utilized points of ways chromosomes malsegregate and the way aneuplody originates. the newest recommendations hired to check chromosome segregation and in addition how to be certain aneugenic chemical compounds are defined.

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93, 515-520. Rattner, J. B. (1987). The organization of the mammalian kinetochore: a scanning electron microscope study. ). 95, 175-181. Rattner, J. B. (1991). The structure of the mammalian centromere. Bioessays. 13,51-56. Rattner, J. B. and Bazett-Jones, D. P. (1989). Kinetochore structure: Electron spectroscopic imaging of the kinetochore. J. Cell BioI. 108,1209-1219. Reider, C. L. (1982). The formation, structure and composition of the mammalian kinetochore and kinetochore fiber. Int. Rev. Cytol.

Although we have yet to conclusively identify the cis-acting DNA sequences required for centromere formation, several approaches to this problem have uncovered some interesting potential candidates, and these will be discussed as well. Lastly, we will summarize the recent evidence which suggests that the centromere may participate in cell cycle regulation. Before describing the centromere components, it will be useful to begin with a brief review of centromere morphology. Morphology of the mammalian centromere By the early 1930's, cytologists including Schrader(Schrader, 1936), Lorbeer(Lorbeer, 1934) and Sharp (Sharp, 1929) had reported on a structure which formed on the surface of the chromosome at the major constriction.

E. (1980). Human specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a humanlhamster hybrid cell. Cell. 22, 489-499. , Nozaki, N. and Okazaki, T. (1989). A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite. J. Cell BioI. 109, 1963-1973. Matsumoto, T. and Beach, D. (1991). Premature initiation of mitosis in yeast lacking RCCI or an interacting GTPase. Cell. 66, 347-360. Metzner.

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Chromosome Segregation and Aneuploidy by Baldev K. Vig (auth.), Baldev K. Vig (eds.)

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