By G. W. Richter, Kim Solez
This two-volume set is a entire evaluation of the "in vivo" results in experimental animals brought about through a number of participants of the cytokine kin. The volumes clarify the pharmacological and toxico-pathological impact of such hematopoietic development components as colony stimulating issue, the unconventional components IL-11 and stem mobile components. Then it summarizes the wide spectrum of task of numerous immunostimulatory assays (interleukins IL-1-IL-9) in traditional toxicological assays in addition to effects from transgenic types. The set additionally positive aspects the inflammatory cytokines (IL-1, TNFa and beta, interfereon-g and TGF-beta) effectively reviewed through specialists within the box. The set reports the constitution and distribution of the membrane receptors for those progress components. It addresses the position of varied cytokines in ailment techniques (malaria, sepsis, and meningitis). Volumes 34A and 34B additionally hide the scientific event with development elements (interferons and GM-CSF), which essentially convey that the preclinical facts have been predictive and beneficial for the clinician. each one quantity of "International evaluate of Experimental Pathology" comprises an index, and every bankruptcy contains references
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Additional info for Cytokine-Induced Pathology, Part B : Inflammatory Cytokines, Receptors, and Disease
And Taylor, B. A. ( 1 9 7 8 ) . / Immunol. 120, 422-424. In Vitro and in Vivo Activity and Pathophysiology of Human lnterleukin-8 and Related Peptides Roland Zwahlen Institut für Tierpathologie Universität Bern CH-3001 Bern 9, Switzerland Alfred Walz Theodor Kocher Institut Universität Bern CH-3001 Bern 9, Switzerland Antal Rot Sandoz Forschungsinstitut A-1235 Vienna, Austria I. Introduction II. Induction and Formation III. Biological Activities in Vitro A. Activities on Neutrophils B. Activities on Other Leukocytes IV.
5). C. v. IL-8 injection induced a marked neutrophilia in Chinchilla rabbits, which was present after 15 min and peaked between 1 and 2 hr and remained marked until the end of the observation period (Table II). Histological examination revealed leukostasis and congestion in dilated lung vessels of IL-8-treated animals (not shown). Repeated short-term IL-8 injec tions induced significant histological changes only in the lung. Neutrophil aggregates were found in small to medium-sized lung vessels, whereas accu mulation of individual neutrophils could be observed in lung capillaries.
And Ni, R. X. ( 1 9 8 7 ) . / Immunol. 139, 3406-3415. Ulich, T. , Ni, R. , and Calvin, L. /. Leukocyte Biol. 45, 155-167. van Lanschot, J. , Mealy, K, and Wilmore, D. W. ( 1990). Ann. Surg. 212, 663-670. Waage, A. (1987). Clin. Immunol. Immunopathol. 45, 348-355. , and Espevik, T. /. Exp. Med. 167, 1987-1992. , and Espevik, T. ( 1987). Lancet 1, 355-357. , and Taylor, B. A. ( 1 9 7 8 ) . / Immunol. 120, 422-424. In Vitro and in Vivo Activity and Pathophysiology of Human lnterleukin-8 and Related Peptides Roland Zwahlen Institut für Tierpathologie Universität Bern CH-3001 Bern 9, Switzerland Alfred Walz Theodor Kocher Institut Universität Bern CH-3001 Bern 9, Switzerland Antal Rot Sandoz Forschungsinstitut A-1235 Vienna, Austria I.
Cytokine-Induced Pathology, Part B : Inflammatory Cytokines, Receptors, and Disease by G. W. Richter, Kim Solez