Read e-book online Drugs Affecting Leukotrienes and Other Eicosanoid Pathways PDF

By Bengt Samuelsson (auth.), B. Samuelsson, F. Berti, G. C. Folco, G. P. Velo (eds.)

ISBN-10: 1468478419

ISBN-13: 9781468478419

ISBN-10: 1468478435

ISBN-13: 9781468478433

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So II,coJCH,GH •. , '. I. PA 2. ott • If.. '..... n'C " --{~]" Figure 3. Synthesis of LTB4 (Corey) This route gives always a mixture of 6-cis and 6-trans isarers which can be seperated by RP-h. 1. c. • Last not least d-arabinose and l-arabinose were used in the synthesis29 of leukotriene B3 and its 6-trans isarer. It should also be possible to establish the stereochemisO:y and the absolute configuration of the new discovered lipaxines using derivates derived frau arabinose. The lipaxines are 5,6, 15-trihydroxy-tetraenoic acids of arachidonic acid and 5,14, 15-trihydroxy-eicosatetraenoic acid with uncertain assigmrent of the 6-hydroxygroup which can be in the R or S configuration whereas the stereochemisO:y of rationally reason of the four double bonds should be the sane as described in the publication of Serhan and Samuelsson 30.

4. , Kohen F. , 1983, Chemiluminescence immuno-assay of thromboxane B2' in Advances in prostaglandin, Thromboxane and Leukotriene Research, Vol 11, B. Samuelsson, R. Paoletti and P. Ramwell, Raven Press, New York pp 185. 5. , B. Charbonnel and J. , 1975, Radioimmuno-assay of prostaglandins F~, E1 and E2 in human plasma, Eur. J. , 5:311. 6. Massoulie J. , 1976, Affinity chromatography of acetylcholinesterase. The importance of hydrophobie interactions, Eur. J. , 68:531. 7. Massoulie J. , 1982; The molecular forms of cholinesterase and acetylcholinesterase in vertebrates, Ann.

Ae-OH-LTI• • I-COOH-LT" ~ " ...... M ~ ~/-Sit ~ Olt ~c Olt ~ "Sit \ dl-HETE. -. "~It ..... : Ölt "~It H"': _ HETE. Olt Figure 2. via oxidation of the Iresylate cx::curs via an ~-1 type reaction leading always to the racemic fonn of 5-HPEl'E 14. The synthesis of the 15 (S) -HErr'E or HPEl'E can be easily achieved using the enzymatic oxidation of arachidonie acid in basic solution with soybean liIX>XYgenase type I 15. The connection between 5-HErr'E, 5-HPEl'E, LTA4 and the "slow reacting substance of anaphylaxis" (SRS-A) later narood leukotriene C4 ' D4 , E4' F 4 was suggested by the evidence that both species are Iretabolites of arachidonie acid and can not be inhibited.

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Drugs Affecting Leukotrienes and Other Eicosanoid Pathways by Bengt Samuelsson (auth.), B. Samuelsson, F. Berti, G. C. Folco, G. P. Velo (eds.)

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