By Kelli A Duncan
This e-book demystifies, deconstructs, and concurrently humanizes the sphere of estrogen-mediated neuroprotection following TBI, making the topic approachable to either researchers and complex scholars. Bringing jointly top researchers and practitioners to provide an explanation for the root for his or her paintings, equipment, and their effects, chapters discover what's identified in regards to the position of estrogens following harm to the mind. With issues overlaying induction of estrogen reaction, outcomes of estrogen motion, and mechanisms underlying estrogen mediated neuroprotection, Estrogen results on worrying mind Injury is of serious significance to lecturers, researchers, and clinicians attracted to the function that estrogens play following nerve-racking mind injury.
- Written to supply a foundational view of estrogens as neuroprotectors in TBI, acceptable for either researchers and complex students
- Data research bins in each one bankruptcy aid with facts interpretation and provide directions on how most sensible to appreciate results.
- A multidisciplinary method of the equipment, matters, empirical findings within the box of estrogen mediated neuroprotection.
- Detailed concentrate on how stories relate and construct upon one another and the methods varied equipment of research tell each one other.
- Written to supply clinicians with new and constructing healing procedures for sufferers of their field.
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Additional resources for Estrogen Effects on Traumatic Brain Injury: Mechanisms of Neuroprotection and Repair
4). It is of great interest to determine if E2 synthesized in the brain influences circulating E2 levels, and while this is a possibility, much research has been conducted on the actions of brain-derived E2 acting exclusively in the brain. , 2011). The process involves the presence of synaptically located aromatase regulating the rapid local synthesis of E2, followed by the activation of extranuclear ER coupled with intracellular signaling cascades via second messenger systems. ESTROGEN EFFECTS ON TRAUMATIC BRAIN INJURY 18 2.
Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gammainducible protein-10 by astrocytes exposed to inflammatory challenge in vitro. Glia. 58 (1), 93À102. , 2014. Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17betaestradiol biosynthesis in endometrial carcinoma microenvironment. Int. J. Cancer. 135 (2), 282À294. , 2003. Astrocytes and brain injury. J. Cereb. Blood Flow. Metab. 23 (2), 137À149. , 2006. Gender differences in neurological disease: role of estrogens and cytokines.
13, 760À779. , 2005. Differential distribution of estrogen receptor (ER)-α and ER-β in the midbrain ESTROGEN EFFECTS ON TRAUMATIC BRAIN INJURY REFERENCES 27 raphe nuclei and periaqueductal gray in male mouse: predominant role of ER-β in midbrain serotonergic systems. Neuroscience. 130, 445À456. , 2003. The neuroprotective effects of estrogen on the aging brain. Exp. Gerontol. 38, 109À117. , 2003. Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain.
Estrogen Effects on Traumatic Brain Injury: Mechanisms of Neuroprotection and Repair by Kelli A Duncan