By Alan H. Cruickshank
The fresh advances within the concepts for imaging the pancreas with out surgical interven tion have diminished the inaccessibility of the pancreas. in spite of the fact that, even if convinced lesions of the pancreas can now be known and localised with out an operation, the pathology of the pancreas is still extra completely investigated. additionally, the just about unrelated exocrine and endocrine features of the pancreas have resulted in the administration of alternative pancreatic ailments by means of assorted teams of experts, whereas the consequences of basically non pancreatic illnesses upon the pancreas have tended to flee acceptance. Even within the post-mortem room the pancreas is usually inadequately tested, and autolysis may well make microscopic exam unrewarding. This publication is an test through a common histopatholo gist to make on hand a few of his event of many of the features of pancreatic ailment that he has encountered in the course of his operating profession. My curiosity within the pathology of the pancreas used to be aroused whereas operating with Prof. Arnold Rice wealthy of the Johns Hopkins health center, Baltimore. wealthy himself, in his prior paintings, had endured the culture, started within the comparable division of pathology through Opie, of accomplishing morbid anatomical and experimental reviews on pancreatic sickness. wealthy later turned extra curious about paintings on tuberculosis and at the collagen ailments yet his inter est in affliction of the pancreas endured and the paintings he disbursed to me integrated an experi psychological examine of chemically precipitated diabetes mellitus.
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The new advances within the suggestions for imaging the pancreas with out surgical interven tion have lowered the inaccessibility of the pancreas. notwithstanding, even though convinced lesions of the pancreas can now be recognized and localised with out an operation, the pathology of the pancreas is still extra completely investigated.
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Additional info for Pathology of the Pancreas
In a later series of 212 cases from the Mayo Clinic, all of which were clinical cases and not cases in which the aberrant tissue had been found incidentally at autopsy, Dolan et al. (1974) reported that the stomach was the site in 81 cases, the duodenum in 77 and the upper jejunum in 33, followed by Meckel's diverticulum in 11 and the ileum in three. There were single cases in which the sites were: the common bile duct, the umbilicus, the gall bladder, the hilus of the spleen, the papilla of an accessory pancreatic duct, outside the stomach near the left gastric artery, and anterior to the duodenal end of the main pancreas.
They reported the case of a female child with a gestational age of 41 weeks by dates, but with clinical and radiological features more in keeping with 36 weeks, findings they interpreted as indications of intrauterine growth retardation. A left diaphragmatic hernia was recognised and was repaired soon after birth, but the child died at the age of 24 h. At autopsy there was no recognisable pancreatic tissue at the usual site nor was any exocrine or endocrine pancreatic tissue found on microscopic examination of all the organs.
Raven Press, New York, pp 45-53 England MA (1983) A colour atlas of life before birth. Normal fetal development. Wolfe Medical Publications, London, p 127 Gepts W (1981) Islet changes in human diabetes. In: Cooperstein SJ, Watkins D (eds) The islets of Langerhans. Academic Press, New York, pp 339-341 Heitz PU, Beglinger C, Gyr K (1984) Anatomy and physiology of the exocrine pancreas. In: Kloppel G, Heitz HU (eds) Pancreatic pathology. Churchill Livingstone, London, pp 3-21 Henderson JR, Daniel PM, Fraser PA (1981) The pancreas as a single organ: tlIe influence of the endocrine upon the exocrine part of the gland.
Pathology of the Pancreas by Alan H. Cruickshank