New PDF release: The Developing Human Brain. Growth and Epidemiologic

By F. H. Gilles

ISBN-10: 072367017X

ISBN-13: 9780723670179

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Extra resources for The Developing Human Brain. Growth and Epidemiologic Neuropathology

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Wt. by weeks • Twins (0 ε 600 X LU 5 z < 400 ω 200 80 40 TOTAL AGE (weeks) Figure 6-6 Nonlinear model of entire BRNDAT (N = 1,537) population (solid curve) and subgroups N = 1,262 (open circle) and N = 1,389 (open square) covering the age ranges indicated and edited by removal of highly unlikely data points (see text). The large closed circles represent the mean brain weight at individual weeks of total age; the small closed circles represent brain weights of individuals from twin pairs. 0528 The mean brain weight for the entire group is also indicated for each gestational week.

00 GESTATIONAL AGE (weeks) Figure 6-7 Gompertz prediction (heavy line) and 95% confidence band (N = 1,233) of edited BRNDAT population covering 15 to 60 weeks. [Brain weight (gm), gestational age (weeks) total age after term]. Data points through 65 weeks of total age are included, although the statistical regression did not use cases beyond 44 weeks. 0498LY) y = 1,065 e e (6-10) based on N = 1,233 cases. This curve is shown with data points and the 95% confidence band in Fig. 6-7; included are data points for cases through 65 weeks total age, although the statistical regression did not use these additional cases beyond week 44.

These major roadblocks in dating young spec­ imens are magnified in obtaining quantitative organ data. Of specific interest to this study is the weight and size of the fetal human brain; it appears that direct measurements of the brain may be unavailable before about 12 to 15 weeks gestation, and values in this range are suspect because of the friable nature of the minute pieces of tissue and the rapid change in water content during the process of abortion, tissue extraction, and preparation for study.

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The Developing Human Brain. Growth and Epidemiologic Neuropathology by F. H. Gilles


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